HEPATOTOXICITY相关论文
Acetaminophen(APAP)overdose can induce liver injury and is the most frequent cause of acute liver failure in the United ......
The immune checkpoints,cytotoxic T-lymphocyte-associated antigen 4(CTLA-4)and pro-grammed cell death protein-1/ligand-1(......
目的:探讨儿童急性淋巴细胞白血病(acute lymphoblastic leukemia，ALL)中n NUDT15基因单核苷酸多态性(single nucleotide poly......
Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebra
Tripterygium wilfordii multiglycoside(GTW)is a commonly used compound for the treatment of rheumatoid arthritis(RA)and i......
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries.However,PMR-associated hepatoto......
The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dios
Diterpenoid lactones (DLs),a group of furan-containing compounds found in Dioscorea bulbifera L.(DB),have been reported ......
Fructus Psoraleae,which is commonly consumed for the treatment of osteoporosis,bone fracture,and leucoderma,induces live......
...
The protectiv effects of totoal saponin extracted from codonopsis lanceolata on diethylnitrosamine-i
Previously, we demonstrated that the crude saponin from codonopsis lanceolata has striking anti-mutagenic effects, and i......
This study is to evaluate hepatotoxicity induced by potassium dichromate in chickens via drinking water.Seventy-two Hyla......
Supramolecular inclusion of nitidine chloride reduced its hepatotoxicity and improved its anticancer
Nitidine chloride(NC),a natural alkaloid isolated from the root of Zanthoxylum nitidum,has demonstrated promising antica......
Hepatotoxicity of pyrrolizidine alkaloid-containing natural products and development of the mechanis
It is now well recognized that the concept of no adverse effect and/or toxicity of traditional Chinese medicines (TCMs) ......
Protective effects of electrolyzed reduced water on carbon tetrachloride induced oxidative damage in
...
...
Role of miR-155 in FluorooctaneSulphonate-induced Oxidative Hepatic Damage via the Nrf2-dependent Pa
Studies have demonstrated that perfluorooctanesulphonate(PFOS)tends to accumulate in the liver and is capable to cause h......
Geldanamycin (GA),a benzoquinone ansamycin,was reported as the first heat shock protein 90 (Hsp90) inhibitor.GA binds to......
Diosbulbin B (DIOB), a furanoid, is a major constituent of herbal medicine Dioscorea bulbifera L.Exposure to DIOB caused......
Difenoconazole belongs to the group of triazole compounds, and has been widely used as an environmental fungicide.This l......
Ethanol,the most popular drink all over the world,has recently been shown to be an effective autophagy regulator.Cucurbi......
Green tea has a considerable amount of polyphenolic catechins and has been promoted to have beneficial effects on health......
Differential Proteomic Analysis of Saikosaponins of Radix Bupleuri induced Hepatotoxicity in Mice Us
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Bupleuri (RB) has been popularly used for treating many liver diseases such as chr......
Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in nor
AIM To investigate the effects of dietary intake of Fructus Schisandrae chinensis (FSC), both aqueous and ethanolic extr......
Hepatoxicity of major constituents and extractions of Polygoni Multiflori Radix and Polygoni Multifl
Aim of the study: Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) were traditionally wid......
NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chines
1.The present study investigated the relationship between antituberculosis (anti-TB) drug-induced hepatotoxicity and gen......
SM02-P01:Synthesis and biological activity of NO-donor-tacrine hybrids as potent anti-Alzheimer drug
...
Hepatotoxicity is a major cause of drug withdrawal from the market.To reduce the drug attrition induced by hepatotoxicit......
...
Drug-induced liver injury(DILI)is an uncommon event in clinical practice,which makes knowing its true incidence difficul......
Insights into reproductive toxicity in medaka fish upon chronic exposure to MC-LR and Microcystis ex
...
Development of an optimized cytotoxicity assay system for CYP3A4-mediatedmetabolic activation via mo
Objective Drug-induced hepatotoxicity is often caused by cytochrome P450 (CYP)-dependent metabolism of drugs into re......
β-Diketone antibiotics (DKAs) are a"pseudo-persistent" environmental pollutant,however, currently, there are limite......
Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation
Background Lapatinib has been used in combination with capecitabine or paclitaxeltotreatpatients with progressive HE......
Objective:To evaluate the effect of p-coumaric acid against adriamycin-induced hepatotoxicity in rats.Methods:The rats w......
Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut
Berberine has been shown to reduce acute liver injury although the underlying mechanism is not fully understood.Because ......
Objective: To explore the effect of cellular immunity in halothane hepatitis. Methods: Hepatotoxicity model was establis......
对乙酰氨基酚( APAP)是乙酰苯胺类药物，为非那西丁代谢产物，因其常用剂量安全有效，是临床上常用的解热镇痛药。近期，美国食品药品管理......
Hot aqueous leaf extract of Lasianthera africana (Icacinaceae) attenuates rifampicin-isoniazid-induc
Objectives:The aim of this study is to evaluate the hepatoprotective effect of Lasianthera africana (Icacinaceae) agains......
Rising rates of obesity across the globe have been associated with an increase in the use of herbal preparations for wei......
目的 考察有机阴离子转运多肽1B1(OATP1B1)基因多态性、利福平稳态谷浓度及肝毒性之间的相关性.方法 入选90例结核病患者,连续多次......
Ca2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hy
AIM: To investigat the relation between hepatotoxicity of halothane and sevoflurane and altered hepatic calcium homeosta......
Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, acce......
Hepatoprotective activity of brown algaPadina boergesenii against CCl4 induced oxidative damage in W
Objective:To investigate the protective effects of brown algaPadina boergesenii(P. boergeseii) against carbon tetrachlor......
Protective effect ofAmorphophallus campanulatus (Roxb.) Blume. tuber against thioacetamide induced o
Objective:To identify the phytochemical constituents ofAmorphophallus campanulatus (A. campanulatus) tuber and to evalua......
Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against para
Objective: To investigate the hepatoprotective activity of methanolic leaf extract of Cyatheagigantea (C. gigantea) agai......
Effects of four Indian medicinal herbs on Isoniazid-,Rifampicin- and Pyrazinamide-induced hepatic in
AIM: To evaluate and compare the hepatoprotective and immunomodulatory effects of Curcuma longa (CL), Ocimum sanctum (OS......
Hepatoprotective potential of ethanolic extract ofZiziphus oenoplia (L.) Mill roots against antitube
ABSTRACT Objective:To evaluate the hepatoprotective potential of ethanolic (50%) extract ofZiziphus oenoplia (L.) Mill (......
